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Response to: ‘response to: irritable bowel syndrome symptoms in axial spondyloarthritis more common than among healthy controls: is it an overlooked comorbidity?’ by Proft et al.
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  1. Johan Karlsson Wallman1,2,
  2. Elisabeth Mogard1,2,
  3. Jan Marsal3,4,
  4. Kristofer Andréasson1,2,
  5. Anna Jöud5,
  6. Mats Geijer6,7,
  7. Lars Erik Kristensen8,
  8. Elisabet Lindqvist1,2,
  9. Tor Olofsson1,2
  1. 1 Department of Clinical Sciences Lund, Rheumatology, Lund University, Lund, Sweden
  2. 2 Department of Rheumatology, Skåne University Hospital Lund, Lund, Sweden
  3. 3 Department of Clinical Sciences Lund, Gastroenterology, Lund University, Lund, Sweden
  4. 4 Department of Gastroenterology, Skåne University Hospital Lund, Lund, Sweden
  5. 5 Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
  6. 6 Department of Radiology, Sahlgrenska University Hospital, Region Västra Götaland and Department of Radiology, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden
  7. 7 Department of Clinical Sciences Lund, Diagnostic Radiology, Lund University, Lund, Sweden
  8. 8 Department of Rheumatology, Copenhagen University Hospital, Frederiksberg and Bispebjerg, Parker Institute, Copenhagen, Denmark
  1. Correspondence to Dr Johan Karlsson Wallman, Department of Rheumatology, Skåne University Hospital Lund, 22185 Lund, Sweden; johan.81.karlsson{at}gmail.com

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We appreciate the correspondence by Proft et al regarding our study entitled ‘Irritable bowel syndrome symptoms in axial spondyloarthritis more common than among healthy controls: is it an overlooked comorbidity?’,1 2 and thank Annals of the Rheumatic Diseases for the opportunity to respond. We also acknowledge the major contributions of Proft et al to the field of spondyloarthritis (SpA) research.

Regarding our main result, that irritable bowel syndrome (IBS) symptoms are significantly more common among patients with axial SpA without known inflammatory bowel disease (IBD) (n=182) than in healthy controls (n=50), Proft et al point out that the increased prevalence is likely due to other causes than actual clinical IBS (in particular gut inflammation and side effects of non-steroidal anti-inflammatory drug (NSAID) use).

In response to this, we would first like to draw attention to the rule-out character of the ROME III criteria used to diagnose IBS, as also brought up by Proft et al. According to these, a clinical IBS diagnosis requires both a typical constellation of gastrointestinal symptoms, as defined by the criteria, and the exclusion of organic causes such as IBD or malignancies. The main finding of our study, that 30% of the axial SpA patients in the well-characterised SPARTAKUS cohort reported IBS symptoms, as opposed to 16% of healthy controls (sex/age-adjusted OR 2.5; p=0.036), refers to self-reported symptoms, as defined by the ROME III criteria, but irrespective of their underlying cause (and hence not per se meeting the exclusion condition). This important distinction—between IBS symptoms and a clinical IBS diagnosis—is made throughout our report.

In the second part of our study, we then performed a hypothesis-generating analysis of potential drivers behind the observed IBS symptoms. Similar to Proft et al, a priori we also considered gut inflammation (in the form of microscopic gut inflammation or even undiagnosed IBD) and NSAID side effects among the more plausible explanations behind these symptoms.

Regarding gut inflammation, faecal calprotectin (F-calprotectin) is a standard clinical and highly sensitive biomarker of IBD disease activity. In SpA, F-calprotectin (as well as C-reactive protein) has also been shown to be significantly elevated among patients displaying microscopic (histological) gut inflammation at ileocolonoscopy, with a reported optimal F-calprotectin cut-off of 85 mg/kg for the detection of such cases.3 Moreover, two other studies have demonstrated the presence of macroscopic inflammatory lesions at capsule endoscopy and/or ileocolonoscopy in SpA patients with previously undiagnosed IBD to be significantly associated with elevated F-calprotectin (>100 mg/kg).4 5 In our study, adjustment for F-calprotectin levels did not at all change the results of our main analysis, comparing the prevalence of gut symptoms meeting ROME III criteria for IBS between axial SpA patients and controls. Nor did we find any overall association between the presence of IBS symptoms and F-calprotectin elevation in the axial SpA group, when applying different previously suggested F-calprotectin cut-offs, and the geometric means of F-calprotectin in patients with and without IBS symptoms were very similar (31 vs 35 mg/kg). Finally, the association between IBS symptoms and female sex in the present work (adjusted OR 2.4 vs males; p=0.017) contrasts with the strong male predominance of microscopic (histological) gut inflammation (OR 8.9 vs females; p=0.035) observed by van Praet et al among axial SpA patients without diagnosed IBD,6 lending further support to the view that undiscovered gut inflammation is unlikely to be the main driver behind the reported IBS symptoms in our study.

In respect to antitumour necrosis factor (TNF) therapy, initiation of adalimumab in axial SpA patients with newly discovered subclinical IBD has been shown to simultaneously reduce macroscopic gut lesions and F-calprotectin levels.4 Moreover, ongoing treatment with monoclonal antibody-type anti-TNF agents among axial SpA patients without known IBD has been associated with significantly lower F-calprotectin levels than in patients receiving etanercept or no anti-TNF treatment.7 Despite such previously demonstrated effects on potential low-grade gut inflammation, in our study IBS symptoms were reported by 40% (n=19) of the 48 patients with ongoing monoclonal antibody-type anti-TNF therapy, while the corresponding figure among the remaining 134 patients was 27% (n=36), thus rather pointing towards a disconnect between gut inflammation and IBS symptoms in our cohort.

In regards to potential NSAID side effects, adjustment for NSAID-use during the last 3 months only marginally decreased the point-estimate OR for the axial SpA patients versus controls difference in reported IBS symptoms from 2.5 to 2.2, although statistical significance was lost (p=0.067). Within the axial SpA group, there was also a positive univariate association between NSAID-use and the presence of IBS symptoms, but this did not remain statistically significant in the multivariate model. Furthermore, NSAID enteropathy is known to result in elevated F-calprotectin levels,7 8 but we found no clear association between IBS symptoms and F-calprotectin.

In our multivariate analysis, the factors most strongly related to the presence of IBS symptoms in the axial SpA group were female sex (which is also over-represented among clinical IBS patients in the general population9) and comorbid fibromyalgia (known to be closely associated with clinical IBS in the general population10). As previously shown for SpA patients with comorbid fibromyalgia,11 all patient-reported outcomes, but not the evaluator’s global assessment of disease activity, were also significantly worse in our axial SpA group reporting IBS symptoms.

In light of the various aspects brought up above, we thus hypothesised that clinical IBS, similar to fibromyalgia, may be over-represented in axial SpA, explaining a relevant part of the observed increase in self-reported IBS symptoms relative to controls in our main analysis. We agree with Proft et al that the lack of endoscopic examinations is a limitation of this approach and call for future studies including such assessments to try to further elucidate what the increased frequency of IBS symptoms in the axial SpA population really represents. We note, however, that the authors of a previous study, examining SpA patients with capsule endoscopy and ileocolonoscopy, also hypothesise clinical IBS to be relatively frequent in this disease, based on common gastrointestinal complaints among patients with normal endoscopic examinations.5 Finally, we fully share the viewpoint of Proft et al, that in the clinical setting, when seeing SpA patients presenting with gastrointestinal symptoms, a thorough examination of potential causes should be performed, including (but not limited to) considerations regarding gut inflammation and NSAID entheropathy.

Acknowledgments

We are indebted to all patients, controls and staff involved in the SPARTAKUS study and to the Department of Clinical Immunology and Transfusion Medicine, Skåne University Hospital, Lund, Sweden, for performing the F-calprotectin analyses. A particular thanks to our research nurse Miriam Walsh Ingelström for study coordination.

References

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Footnotes

  • Handling editor Josef S Smolen

  • Contributors TO and JKW participated in study design, acquisition of data, analysis and interpretation of data, and draft and revision of the manuscript. EM and EL participated in study design, acquisition and interpretation of data, and revision of the manuscript. JM, KA, AJ, MG and LEK participated in study design, interpretation of data and revision of the manuscript. All authors read and approved the final manuscript.

  • Funding This study was supported by unrestricted grants from Skåne University Hospital, the Swedish Rheumatism Association, the Anna-Greta Crafoord Foundation, the Kock Foundation and the Lundgren Foundation. Funding from the Faculty of Medicine, Lund University, contributed to financing EM’s research time. Funding from the Hedlund Foundation and the Österlund Foundation contributed to financing JM’s research time. Grants to researchers in public health care from the Swedish government (ALF) contributed to financing JKW’s, JM’s, KA’s and TO’s research time. The sponsors had no role in study design, data collection, data analysis, data interpretation or writing of the report.

  • Competing interests JKW has received consultancy fees from AbbVie, Celgene, Eli Lilly, Novartis and UCB Pharma (unrelated to the present work). JM has received investigator-initiated study funding from AbbVie, Ferring, Pfizer and Takeda, and has served as a speaker, a consultant and/or an advisory board member for AbbVie, Ferring, Janssen-Cilag, Svar/EuroDiagnostica, Takeda and Tillotts (unrelated to the present work). MG has received consultancy fees from AbbVie, Novartis and Pfizer (unrelated to the present work). LEK has received consultancy and speaker’s bureau fees from AbbVie, Amgen, Biogen, Bristol-Myers Squibb (BMS), Celgene, Eli Lilly, Janssen Pharmaceuticals, Merck, Sharp & Dohme (MSD), Novartis, Pfizer, Roche, Sanofi and UCB Pharma (unrelated to the present work). Remaining authors reported no competing interests.

  • Patient consent for publication Not required.

  • Ethics approval Ethical approval for the SPARTAKUS study has been granted by the Regional Ethics Committee in Lund, Sweden (Dnr. 2015/436 with amendment Dnr. 2018/238). Oral and written informed consent was granted by all patients and controls before entry in the study.

  • Provenance and peer review Commissioned; internally peer reviewed.

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