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Application of MS score in macrophage activation syndrome patients associated with adult onset Still’s disease
  1. Ran Wang1,
  2. Ting Li2,
  3. Shuang Ye2,
  4. Wenefng Tan3,
  5. Cheng Zhao4,
  6. Yisha Li5,
  7. Chunde Bao1,
  8. Qiong Fu1
  1. 1Department of Rheumatology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China
  2. 2Department of Rheumatology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital South Campus, Shanghai, China
  3. 3Department of Rheumatology, The First Affiliate Hospital of Nanjing Medical University, Nanjing, China
  4. 4Department of Rheumatology, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
  5. 5Department of Rheumatology, Xiangya Hospital of Central South University, Changsha, China
  1. Correspondence to Dr Qiong Fu, Department of Rheumatology, Shanghai Jiao Tong University School of Medicine, Affiliated Renji Hospital, Shanghai, China; fuqiong5{at}

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We read with great interest the article by Minoia et al which named development and initial validation of the macrophage activation syndrome (MAS)/systemic juvenile idiopathic arthritis (sJIA) (MS) score for diagnosis of MAS in sJIA.

MAS is a life-threatening complication of rheumatic disorders, including sJIA, adult-onset Still’s disease (AOSD) and lupus.1–4 Timely diagnosis and appropriate treatment of MAS are particularly important to improve the prognosis of MAS patients. At present, hemophagocytic lymphohistiocytosis (HLH)-2004 and HLH-2009 criteria are widely used to identify MAS associated with AOSD. Hemophagocytic syndrome diagnostic (HS) score was developed previously to facilitate MAS recognition, but still requires validation.5 In 2019, Francesca Minoia et al reported a MS score for classification of sJIA-associated MAS patients.6 Considering that sJIA and AOSD are thought to constitute the …

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