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We thank Campochiaro et al for their interesting comment1 on our work in which we used hierarchical clustering on principal components to define clinically meaningful subgroups of patients with anti-Ku antibodies.2
Among a bi-centric cohort of patients with systemic sclerosis (SSc), Campochiaro et al identified four patients with anti-Ku and retrospectively reviewed these cases.
All patients had increased creatine kinase (CK), three (75%) of whom had interstitial lung disease (ILD). These findings support our observations according to which anti-Ku patients with elevated CK are at risk of ILD.
Of particular interest, Campochiaro et al proposed that myocarditis could further represent a specific feature of anti-Ku patients with elevated CK given that all of their four anti-Ku SSc patients had cardiac magnetic resonance (CMR) imaging established myocarditis according to Lake Louise criteria. Two (50%) had heart failure while the remaining two had subclinical presentation. By contrast, in our cohort, …
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