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The new 2019 SLE European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for systemic lupus erythematosus (SLE) have been recently published.1 These criteria have been developed to find a better equilibrium between specificity and sensitivity compared with the previous criteria (SLE ACR-19972 and SLE Systemic Lupus International Collaborating Clinics (SLICC)3). Even if these criteria have been built for classification, they could be useful in clinical practice in patients with a suspicion of systemic autoimmune disease (AID) to differentiate patients with SLE from patients with another systemic AID, such as primary Sjögren’s syndrome (pSS), scleroderma or myositis. SLE and pSS share biological and clinical similarities. In clinical practice, it is frequently difficult to differentiate these two diseases. Moreover, SLE and Sjögren’s syndrome (SS) may overlap. The aim of this study was to explore the utility of the 2019 SLE EULAR/ACR criteria compared with …