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New 2019 SLE EULAR/ACR classification criteria are valuable for distinguishing patients with SLE from patients with pSS
  1. Florence Assan1,
  2. Raphaele Seror1,2,
  3. Xavier Mariette1,2,
  4. Gaetane Nocturne1,2
  1. 1Rheumatology, AP-HP, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, France
  2. 2Université Paris-Sud, Center for Immunology of Viral Infections and Auto-immune Diseases (IMVA), Institut pour la Santé et la Recherche Médicale (INSERM) UMR 1184, Université Paris-Saclay, Le Kremlin-Bicêtre, France
  1. Correspondence to Professor Xavier Mariette, Rheumatology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux universitaires Paris-Sud – Hôpital Bicêtre, Le Kremlin Bicêtre 94270, France; xavier.mariette{at}aphp.fr

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The new 2019 SLE European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for systemic lupus erythematosus (SLE) have been recently published.1 These criteria have been developed to find a better equilibrium between specificity and sensitivity compared with the previous criteria (SLE ACR-19972 and SLE Systemic Lupus International Collaborating Clinics (SLICC)3). Even if these criteria have been built for classification, they could be useful in clinical practice in patients with a suspicion of systemic autoimmune disease (AID) to differentiate patients with SLE from patients with another systemic AID, such as primary Sjögren’s syndrome (pSS), scleroderma or myositis. SLE and pSS share biological and clinical similarities. In clinical practice, it is frequently difficult to differentiate these two diseases. Moreover, SLE and Sjögren’s syndrome (SS) may overlap. The aim of this study was to explore the utility of the 2019 SLE EULAR/ACR criteria compared with the SLE ACR-19972 and SLE SLICC3 criteria for differentiating patients with SLE from patients with pSS or with an overlap between SLE and SS in clinical practice.

This retrospective study was performed in the Department of Rheumatology, Hopitaux Universitaires Paris Sud, a French reference centre for rare systemic AID. The biological, immunological and clinical data were collected at diagnosis or at the first visit at the centre. We included three different groups of patients:

  • Forty-nine patients with SLE (both inpatients and outpatients followed in the Department of Rheumatology) based on the diagnosis made by the clinician, with exclusion of patients with an association with another connective tissue disease.

  • Forty-nine patients with pSS randomly chosen from the Paris Sud database and compared in a 1:1 ratio with the SLE group. All patients with pSS fulfilled the pSS ACR/EULAR 2016 criteria.4 We excluded patients with an association with another connective tissue disease.

  • Twenty-six patients with SLE/SS overlap based on clinical diagnosis. This last group was made of 13 patients diagnosed with SLE but also presenting objective signs of associated Sjögren’s syndrome, including positive minor salivary glands biopsy (Focus Score ≥1), and/or objective sicca syndrome defined by a salivary flow <0.10 mL/min or a Schirmer test <5 mm at 5 min (n=13), and 13 patients diagnosed with Sjögren’s syndrome, but associated with anti-DNA antibodies.

The characteristics of the patients are presented in table 1. Disease duration was equal between the three groups, and was around 14 years in each arm. Three sets of lupus criteria (SLE ACR-1997, SLE SLICC and 2019 SLE EULAR/ACR criteria) were tested in each group of patients. The 2019 SLE EULAR/ACR criteria were met in 97.9% of patients with SLE and in only 4.2% of patients with pSS. Thus this new set of criteria for SLE offered the best equilibrium between specificity and sensitivity compared with the older criteria and was able to discriminate patients with SLE and pSS in clinical practice.

Table 1

Patient characteristics

Interestingly, patients from the overlap group fulfilled both the criteria for SLE and SS, confirming the mixed presentation and the capacity of the criteria to detect the overlap. The comparison of the three groups showed that some clinical and biological manifestations helped to differentiate the two conditions. Actually, skin involvement, serositis, synovitis, glomerular involvement, lymphopaenia and systemic inflammation were more frequent in SLE. Conversely, cough, myalgia and rheumatoid factor positivity at diagnosis were more frequent in pSS. Systematic assessment of sicca symptoms is easy and might help to differentiate the two conditions. Interestingly, patients with overlap syndrome were likely to present with a more systemic disease than patients with pSS alone as assessed by the EULAR Sjögren’s Syndrome Disease Activity Index.5

To sum up, this study shows that the new 2019 SLE EULAR/ACR criteria for SLE can be useful in clinical practice helping to differentiate between SLE and pSS and detecting overlap presentations.

References

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Footnotes

  • XM and GN contributed equally.

  • Contributors Substantial contributions to study conception and design: RS, GN, XM. Substantial contributions to acquisition of data: FA. Substantial contributions to analysis and interpretation of data: FA, RS, GN, XM. Drafting the article or revising it critically for important intellectual content: FA, RS, GN, XM. Final approval of the version of the article to be published: RS, GN, XM. XM and GN are co-last authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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