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Interferon regulatory factor 7 (IRF7) represents a link between inflammation and fibrosis in the pathogenesis of systemic sclerosis
  1. Minghua Wu1,
  2. Brian Skaug1,
  3. Xiongjie Bi2,
  4. Tingting Mills3,
  5. Gloria Salazar1,
  6. Xiaodong Zhou1,
  7. John Reveille1,
  8. Sandeep K Agarwal4,
  9. Michael R Blackburn3,
  10. Maureen D Mayes1,
  11. Shervin Assassi1
  1. 1Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas McGovern Medical School at Houston, Houston, Texas, USA
  2. 2First Affiliated Hospital of Guangxi University of Science And Technology, Liuzhou, Guangxi, China
  3. 3Department of Biochemistry and Molecular Biology, University of Texas McGovern Medical School at Houston, Houston, Texas, USA
  4. 4Department of Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA
  1. Correspondence to Dr Minghua Wu, Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA; minghua.wu{at}uth.tmc.edu

Footnotes

  • Handling editor Josef S Smolen

  • Contributors MW and SA designed the study. MW, BS, XB, TM and SA were involved in acquisition of data. MW, BS, XB, TM, GS, XZ, JR, SKA, MRB, MDM and SA were involved in interpretation of data. All authors were involved in manuscript preparation and have approved the submitted version of the manuscript.

  • Funding This study was supported by Scleroderma Foundation new Investigator Grant (Wu), an Arthritis National Research Foundation grant (Skaug), R01AR073284 (Assassi) and DoD W81XWH-16-1-0296 (Assassi).

  • Competing interests None declared.

  • Ethics approval The study was approved by the institutional review board of the University of Texas Health Science Center at Houston. The animal protocols were institutionally approved by the University of Texas Health Science Center at Houston Animal Care and Use Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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Footnotes

  • Handling editor Josef S Smolen

  • Contributors MW and SA designed the study. MW, BS, XB, TM and SA were involved in acquisition of data. MW, BS, XB, TM, GS, XZ, JR, SKA, MRB, MDM and SA were involved in interpretation of data. All authors were involved in manuscript preparation and have approved the submitted version of the manuscript.

  • Funding This study was supported by Scleroderma Foundation new Investigator Grant (Wu), an Arthritis National Research Foundation grant (Skaug), R01AR073284 (Assassi) and DoD W81XWH-16-1-0296 (Assassi).

  • Competing interests None declared.

  • Ethics approval The study was approved by the institutional review board of the University of Texas Health Science Center at Houston. The animal protocols were institutionally approved by the University of Texas Health Science Center at Houston Animal Care and Use Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

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