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Proton pump inhibitors are commonly prescribed for the treatment of acid-related gastrointestinal diseases. The association between proton pump inhibitors therapy and other subsequent comorbidities has been extensively explored.1 Recently, a cohort study in USA conducted by Ozen et al published in the Annals of the Rheumatic Diseases reported that proton pump inhibitors therapy was not associated with increased fracture risk in patients with rheumatoid arthritis (HR=0.92; 95% CI 0.80 to 1.06).2 Ozen et al’s study is an important one and deserves a practical value. Some points not shown in the original article are shared with the readers. First, in order to test …
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