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We read with deep interest the article by Chandran V et al,1 which was aimed at identifying soluble biomarkers that differentiate psoriatic arthritis (PsA) from osteoarthritis (OA). Their results showed that cartilage oligomeric matrix protein,monocyte chemoattractant protein-1 and nerve growth factor were found to be independently associated with PsA versus OA in a multivariate analysis, and they obtained the conclusion that a panel of four biomarkers may distinguish PsA from OA. We really appreciate the work that has been done by the authors. However, there are some worthwhile issues that need to be explored.
First, the conclusion ‘A panel of four biomarkers may distinguish PsA from OA’ might be not appropriate. The potential meaning of ‘differentiate PsA from OA’ is that detection of these biomarkers helps to diagnose and distinguish PsA from OA when the clinical manifestations of the two diseases are …
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