Article Text
Correspondence
Adipose stromal vascular fraction and regenerative therapy in SSc: response to the article by Magalon et al
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We read with interest the report by Magalon et al,1 supporting the use of stromal vascular fraction (SVF) derived from adipose tissue, as an innovative autologous biotherapy for patients affected by systemic sclerosis (SSc). This disease is a complex multisystem disorder, characterised by microvascular damage, dysregulation of innate and adaptive immunity and generalised fibrosis in the skin and multiple organs, lacking a specific therapy. SSc is classified into two subsets: limited cutaneous (lcSSc), in which the skin fibrosis is limited to the extremities (hands, arms and face), and diffuse cutaneous (dcSSc), in which the skin fibrosis progresses more rapidly, affecting the trunk and …