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Response to: ‘When binary and continuous responses disagree’ by Dr Ouyang
  1. Kim Lauper,
  2. Delphine Sophie Courvoisier,
  3. Cem Gabay
  1. Division of Rheumatology, Geneva University Hospitals, Geneva, Switzerland
  1. Correspondence to Professor Cem Gabay, Geneva University Hospitals, Geneva 1205, Switzerland; cem.gabay{at}hcuge.ch

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We thank Dr Ouyang for his comment on our work.1

We fully agree that patients stop treatment based, in part, on a lack of satisfactory clinical response. Thus, examining disease activity during follow-up, for instance at 1 year, will be influenced by attrition bias. If patients mostly stop the drug due to inefficacy, comparing only the patients who remain on treatment may lead to the tautological finding that for the people remaining on treatment, the drug is effective.

Another potential explanation for the dissociation between drug retention and other measures of effectiveness could …

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