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Letter in response to article ‘Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis’
  1. Xiaodong Zhou,
  2. John D Reveille
  1. Department of Internal Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA
  1. Correspondence to Professor Xiaodong Zhou, Department of Internal Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA; xiaodong.zhou{at}uth.tmc.edu

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A recent study has raised new questions about the independent association of MICA alleles with ankylosing spondylitis (AS).1 This letter highlights some important issues to be discussed in response to this article.

The authors used imputation to genotype MICA and HLA-B27 in patients with AS and controls of European ancestry. The results appeared discordant with the previous report that showed a strong and human leukocyte antigen (HLA)-B27 independent association between MICA*007:01 and AS in US and Chinese cohorts.2 A common finding was a significant high rate of MICA*007 in patient with AS. The …

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