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Inflammatory cytokines, life-threatening arrhythmias and premature mortality in chronic inflammatory arthritis: time to focus on
  1. Pietro Enea Lazzerini1,
  2. Franco Laghi Pasini1,
  3. Maurizio Acampa2,
  4. Pier Leopoldo Capecchi1
  1. 1Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy
  2. 2Stroke Unit, University Hospital of Siena, Siena, Italy
  1. Correspondence to Dr Pietro Enea Lazzerini, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy; lazzerini7{at}

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We read with much interest the paper by Ntari et al1 and would like to highlight how the high prevalence of fatal arrhythmic events that they found in Tg197 mice might have relevant implications in the clinical setting.

A solid body of data supports the evidence that in patients with chronic inflammatory arthritis (CIA), particularly rheumatoid arthritis (RA), the risk of death is significantly higher than in the general population, and that such a premature mortality is largely related to fatal cardiovascular events.2 In this regard, two population-based studies provided evidence that the prevalence of cardiac arrest (CA) and sudden cardiac death (SCD) is ~2 times higher in patients with RA than in those with no RA.3 4 In addition, in patients with RA, the onset of an acute coronary syndrome is characterised by an increased short-term case …

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