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Tuberculosis (TB) remains a major public health issue: an estimated 10.4 million people developed TB disease and 1.4 million died from it in 2015.1 TB risk was 2.28-fold greater in patients with rheumatoid arthritis (RA) compared with controls,2 and even higher in those receiving biologic therapy.3 Guidelines have recommended that latent TB infection (LTBI) screening should be performed and prophylactic therapy be initiated if LTBI exists.4 Consequently, completion of LTBI treatment is essential for TB control in such patients.
The long therapeutic period and hepatotoxicity are barriers to completing 9-month daily isoniazid (9H) treatment,5 the standard LTBI therapy. Recently, implementing 3-month once-weekly isoniazid plus rifapentine (3HP) by directly observed therapy effectively prevented TB and increased treatment adherence.6 However, 3HP regimen has not been assessed for treating LTBI in RA.
Among 188 …
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