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I read the interesting study entitled ‘Relationship between serum urate concentration and clinically evident incident gout: an individual participant data analysis’ conducted by Dalbeth and colleagues.1 Their study showed the cumulative incidence of gout was increased with the serum urate levels and the cumulative years. The reference level of serum urate below which the risk of damage is low has not been completely clarified. The benchmark dose (BMD) method, first described by Crump in 1984,2 has been widely used in the field …
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