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Cardiovascular events in ankylosing spondylitis: a 2018 meta-analysis
  1. Sylvain Mathieu,
  2. Martin Soubrier
  1. Rheumatology Department, Clermont University, Gabriel Montpied Teaching Hospital, Clermont-Ferrand, France
  1. Correspondence to Dr Sylvain Mathieu, Rheumatology Department, Gabriel Montpied Teaching Hospital, 63003 Clermont-Ferrand, France; smathieu{at}

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In an article published in the Annals of the Rheumatic Diseases, Schieir et al1 reported a trend of increased cardiovascular risk in patients with ankylosing spondylitis (AS). In this letter, we wish to add data to support the conclusions of that article. We performed an updated meta-analysis to investigate the risks of myocardial infarction (MI) and stroke in patients with AS and controls.

We searched PubMed to find reports of interest, published up to February 2018. We included all observational or case/control studies that reported rates of MI or stroke. We calculated the incidences of MI and stroke in a meta-analysis of proportions (inverse variance method) and expressed them in terms of …

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  • Contributors Study concept and design: SM and MS. Acquisition of data: SM. Statistical analysis and interpretation of data: SM. Drafting of the manuscript: SM. Critical revision of the manuscript for important intellectual content: SM and MS.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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