Article Text

other Versions

Download PDFPDF
Dual-energy CT: a new imaging modality for bone marrow oedema in rheumatoid arthritis
  1. Lennart Jans1,
  2. Isabelle De Kock1,
  3. Nele Herregods1,
  4. Koenraad Verstraete1,
  5. Filip Van den Bosch2,
  6. Philippe Carron2,
  7. Edwin H Oei3,
  8. Dirk Elewaut2,4,
  9. Peggy Jacques2
  1. 1Department of Radiology, Ghent University Hospital, Ghent, Belgium
  2. 2Department of Rheumatology, Ghent University Hospital, Ghent, Belgiuim
  3. 3Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
  4. 4Department of Rheumatology and VIB Inflammation Research Center, Unit for Molecular Immunology and Inflammation, Ghent University Hospital, Ghent, Belgium
  1. Correspondence to Prof dr Lennart Jans, Department of Radiology, Ghent University Hospital, Ghent 9000, Belgium; lennart.jans{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Active joint inflammation is a key feature in rheumatoid arthritis (RA). Treatment guidelines for RA,1 including ‘Treat-to-Target’ strategies,2 stress the importance of abrogation of inflammation. MRI clearly demonstrates bone marrow oedema lesions (BMEL) as a sign of inflammation.3 Dual-energy CT (DECT) scanners could provide a new approach to visualise BME.4–7 We investigated if DECT could visualise BME of the hand and wrist in patients with active RA, with MRI-proven BME as a gold standard.

Institutional review board approval was obtained. Twenty consecutive patients with active clinical synovitis of a metacarpophalangeal, proximal interphalangeal or wrist joint provided written informed consent and were included; 9 men and 11 women with a mean age of 60.7 (±10.3) years. Thirteen patients were ACPA positive and 8 were ACPA and RF positive; mean tender joint count and swollen joint count were both 5.9. Mean DAS28 was 4.37 (±1.4). The mean disease duration was 6.6 (±6.1) years. Seventeen patients were treated with conventional disease-modifying antirheumatic drugs, 7 were also treated with biologicals.

DECT was performed on a dual-source CT, data were post-processed with SyngioVia ‘Bone Marrow Oedema’ application …

View Full Text


  • Handling editor Josef S Smolen

  • Contributors LJ: had full access to all of the data in this study and takes responsibility for the integrity of the data and accuracy of the data analysis. LJ, IDK, KV, FVDB, DE and PJ: study design. LJ, NH, FVDB, PC, EO, DE and PJ: acquisition of data. LJ and NH: analysis of data. LJ: statistical analysis. All authors: manuscript preparation, reviewed and approved the manuscript.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Institutional Review Board approval was obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available from this study.