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Letter
European families reveal MHC class I and II associations with autoimmune-mediated congenital heart block

https://doi.org/10.1136/annrheumdis-2018-212953

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    Footnotes

    • SM and MW-H contributed equally.

    • Handling editor Josef S Smolen

    • Contributors SM, NK, IK and MWH conceived the study. AH, LM, SS, HK, CE, SCHBSG, ME, SDC, TK, AR, and JK identified and provided samples from CHB patients and family members. AD imputed HLA allele genotypes. NK and SM analyzed the data with input from IK and MWH. SM and NK wrote the manuscript together with IK and MWH. All authors edited and approved the final manuscript.

    • Funding The study was supported by grants from the Swedish Research Council, the Heart-Lung Foundation, the Stockholm County Council, Karolinska Institutet, the Swedish Rheumatism Association, the King Gustaf Vth 80-year Foundation and the Freemason’s in Stockholm Foundation for Children’s Welfare.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval The Regional Ethic’s Committees in Stockholm, Helsinki, Bergen, Padua and Rome.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Collaborators Amanda Skog; Anders Ekbom; Anders Jonzon; Annika Rydberg; Annika Öhman; Elke Theander; Eva Fernlund; Fredrik Gadler; Gunnar Bergman; Håkan Eliasson; Ingrid Kockum; Joanna Tingström; Katarina Bremme; Kristina Gemzell Danielsson; Linda Lagnefeldt; Malin Hedlund; Marie Wahren-Herlenius; Mats Mellander; Ola Winqvist; Sabrina Meisgen; Stina Salomonsson; Sven-Erik Sonesson; Thomas Skogh; Vijole Ottosson.