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M-CSF and GM-CSF monocyte-derived macrophages in systemic sclerosis: the two sides of the same coin?
  1. Alain Lescoat1,2,
  2. Patrick Jégo1,2,
  3. Valérie Lecureur1
  1. 1Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR_S 1085, F-35000 Rennes, France
  2. 2Médecine Interne, CHU Rennes, Rennes, France
  1. Correspondence to Dr Alain Lescoat, Internal Medicine, CHU South Hospital, Rennes 35203, France; alain.lescoat{at}chu-rennes.fr

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We read with interest the article by Moreno-Moral et al1 exploring the contribution of monocyte-derived macrophages (MDMs) in mediating genetic susceptibility to systemic sclerosis (SSc). By conducting RNA sequencing and genome-wide genotyping in a model of MDMs differentiated by macrophage colony-stimulating factor (M-CSF), this article provides new insights in the activation/polarisation states of blood MDMs in SSc.

In this work, the blood MDMs from 57 patients with SSc present a mixed activation signature state (figure 1 in ref.1): on the one hand, the down-regulation of interferon gamma response is in favour …

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