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Cardiovascular effects of hydroxychloroquine: a systematic review and meta-analysis
  1. Sylvain Mathieu1,
  2. Bruno Pereira2,
  3. Anne Tournadre1,
  4. Martin Soubrier1
  1. 1Department of Rheumatology, Gabriel Montpied Teaching Hospital, Clermont University, Clermont-Ferrand, France
  2. 2Department of Clinical Research and Innovation, Gabriel Montpied Teaching Hospital, Clermont-Ferrand, France
  1. Correspondence to Dr Sylvain Mathieu, Rheumatology Department, Gabriel Montpied Teaching Hospital, Clermont University, Clermont-Ferrand 63003, France; smathieu{at}

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With great interest, we have read Professor Lee’s comments1 concerning our letter ‘Cardiovascular effects of hydroxychloroquine’.2 We completely agree that the relevance of a meta-analysis depends on its completeness, optimally including all published articles and abstracts. Thus, our decision to only search the PubMed database could represent a methodological weakness. However, Rempenault et al3 performed the same meta-analysis with searches of multiple databases (PubMed, EMBASE and Cochrane Library), and …

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