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Response to: ‘Different glucosamine sulfate products generate different outcomes on osteoarthritis symptoms’ by Reginster et al
  1. Jos Runhaar1,
  2. Rianne M Rozendaal1,
  3. Marienke van Middelkoop1,
  4. Hans J W Bijlsma2,
  5. Michael Doherty3,
  6. Krysia S Dziedzic4,
  7. L Stefan Lohmander5,
  8. Timothy McAlindon6,
  9. Weiya Zhang3,
  10. Sita Bierma Zeinstra1,7
  1. 1Department of General Practice, Erasmus University Medical Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands
  2. 2Department of Rheumatology, UMC Utrecht, Utrecht, Netherlands
  3. 3Department of Rheumatology, University of Nottingham, Nottingham, UK
  4. 4Department of Primary Care & Health Services, Keele University, Staffordshire, UK
  5. 5Department of Clinical Sciences, Orthopaedics, Lund University, Lund, Sweden
  6. 6Department of Rheumatology, Tufts Medical Center, Boston, Massachusetts, United States
  7. 7Department of Orthopaedics, Erasmus University Medical Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands
  1. Correspondence to Jos Runhaar; j.runhaar{at}

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We appreciate the interest that Reginster and colleagues1 showed in our publication on subgroup effects of oral glucosamine for osteoarthritis (OA).2 We are pleased that the eLetter authors do not put forward any critique of our publication that requires our justification or clarification.

As highlighted by the authors,1 the effectiveness of oral glucosamine products for knee and hip OA symptoms has been questioned. Nevertheless, due to the heterogeneous nature of the disease, whether certain subgroups of patients with OA could benefit from glucosamine has not been excluded. Since available randomised controlled trials are usually not powered to show subgroup effects, …

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