Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling

Chih-Wei Chen; Christian Beyer; Jun Liu; Christiane Maier; Chun Li; Thuong Trinh-Minh; Xiaohan Xu; Stuart H Cole; Mindy H Hsieh; Nicholas Ng; Alana Althage; Shelly Meeusen; Shifeng Pan; Eric C Svensson; H Martin Seidel; Georg Schett; Peter Gergely; Jennifer L Harris; Jörg H W Distler

doi:10.1136/annrheumdis-2016-210294

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Basic and translational research

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Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling

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Chih-Wei Chen Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Christian Beyer Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Jun Liu Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Christiane Maier Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Chun Li Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Thuong Trinh-Minh Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Xiaohan Xu Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Stuart H Cole Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Mindy H Hsieh Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Nicholas Ng Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Alana Althage Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Shelly Meeusen Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Shifeng Pan Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Eric C Svensson Translational Medicine Autoimmunity Novartis Institutes for Biomedical Research, Basel, Switzerland PubMed articles Google scholar articles
H Martin Seidel Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Georg Schett Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Peter Gergely Translational Medicine Cardiovascular, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Jennifer L Harris Genomics Institute of the Novartis Research Foundation, San Diego, California, USA PubMed articles Google scholar articles
Jörg H W Distler Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles

Correspondence to Dr Jörg H W Distler, Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, PO Box, Glücksstr.4a, Erlangen D-91054, Germany; oerg.distler{at}uk-erlangen.de

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Citation

Chen C, Beyer C, Liu J, et al

Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling

Annals of the Rheumatic Diseases 2017;76:773-778.

Publication history

Received August 1, 2016
Revised December 22, 2016
Accepted January 8, 2017
First published February 2, 2017.

Online issue publication

October 31, 2019

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