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  • Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

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Basic and translational research
Extended report
Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

Authors

  • Michael J Ombrello Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Victoria L Arthur Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Elaine F Remmers Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Anne Hinks Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, Manchester, UK PubMed articlesGoogle scholar articles
  • Ioanna Tachmazidou Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, UK PubMed articlesGoogle scholar articles
  • Alexei A Grom Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Dirk Foell Department of Pediatric Rheumatology and Immunology, University Hospital Münster, Münster, Germany PubMed articlesGoogle scholar articles
  • Alberto Martini Department of Pediatrics, University of Genova, Genoa, Italy Pediatrics II Unit, Giannina Gaslini Institute, Genoa, Italy PubMed articlesGoogle scholar articles
  • Marco Gattorno Pediatrics II Unit, Giannina Gaslini Institute, Genoa, Italy PubMed articlesGoogle scholar articles
  • Seza Özen Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey PubMed articlesGoogle scholar articles
  • Sampath Prahalad Departments of Pediatrics and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA Children's Healthcare of Atlanta, Atlanta, Georgia, USA PubMed articlesGoogle scholar articles
  • Andrew S Zeft Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio, USA PubMed articlesGoogle scholar articles
  • John F Bohnsack Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA PubMed articlesGoogle scholar articles
  • Norman T Ilowite Department of Pediatrics, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, New York, USA PubMed articlesGoogle scholar articles
  • Elizabeth D Mellins Department of Pediatrics, Stanford University, Stanford, California, USA PubMed articlesGoogle scholar articles
  • Ricardo Russo Service of Immunology and Rheumatology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina PubMed articlesGoogle scholar articles
  • Claudio Len Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil PubMed articlesGoogle scholar articles
  • Maria Odete E Hilario Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil PubMed articlesGoogle scholar articles
  • Sheila Oliveira Universidade Federal de Rio de Janeiro, Rio de Janeiro, Brazil PubMed articlesGoogle scholar articles
  • Rae S M Yeung Department of Pediatrics, University of Toronto, Toronto, Canada Department of Immunology, University of Toronto, Toronto, Canada Institute of Medical Science, University of Toronto, Toronto, Canada PubMed articlesGoogle scholar articles
  • Alan M Rosenberg Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada PubMed articlesGoogle scholar articles
  • Lucy R Wedderburn Institute of Child Health, University College London, London, UK Center of Paediatric and Adolescent Rheumatology, University College London, London, UK PubMed articlesGoogle scholar articles
  • Jordi Anton Pediatric Rheumatology Unit, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Johannes-Peter Haas German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany PubMed articlesGoogle scholar articles
  • Angela Rosen-Wolff University Hospital Cal Gustav Carus, Dresden, Germany PubMed articlesGoogle scholar articles
  • Kirsten Minden Department of Rheumatology and Clinical Immunology, Charité -University Medicine, Berlin, Germany Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany PubMed articlesGoogle scholar articles
  • Klaus Tenbrock Department of Pediatrics, RWTH Aachen University, Aachen, Germany PubMed articlesGoogle scholar articles
  • Erkan Demirkaya Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey PubMed articlesGoogle scholar articles
  • Joanna Cobb Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, Manchester, UK National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Elizabeth Baskin Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Sara Signa Department of Pediatrics, University of Genova, Genoa, Italy PubMed articlesGoogle scholar articles
  • Emily Shuldiner Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Richard H Duerr Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Jean-Paul Achkar Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, USA Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA PubMed articlesGoogle scholar articles
  • M Ilyas Kamboh Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Kenneth M Kaufman Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Leah C Kottyan Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Dalila Pinto Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articlesGoogle scholar articles
  • Stephen W Scherer The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Marta E Alarcón-Riquelme Center for Genomics and Oncological Research, Pfizer-University of Granada-Andalusian Government, Granada, Spain Unit of Chronic Inflammatory Diseases, Institute for Environmental Medicine, Karolinska Institutet, Solna, Sweden PubMed articlesGoogle scholar articles
  • Elisa Docampo Interdisciplinary Cluster for Applied Genoproteomics-Université de Liège, Liège, Belgium Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Xavier Estivill Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, and Universitat Pompeu Fabra (UPF), Barcelona, Spain Sidra Medical and Research Centre, Doha, Qatar PubMed articlesGoogle scholar articles
  • Ahmet Gül Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey PubMed articlesGoogle scholar articles
  • British Society of Pediatric and Adolescent Rheumatology (BSPAR) Study Group, Inception Cohort of Newly Diagnosed Patients with Juvenile Idiopathic Arthritis (ICON-JIA) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group
    Google scholar articles
  • Carl D Langefeld Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • Susan Thompson Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Eleftheria Zeggini Human Genetics, The Wellcome Trust Sanger Institute, Hinxton, UK PubMed articlesGoogle scholar articles
  • Daniel L Kastner Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Patricia Woo Center of Paediatric and Adolescent Rheumatology, University College London, London, UK PubMed articlesGoogle scholar articles
  • Wendy Thomson Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, Manchester, UK National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Michael J Ombrello, Translational Genetics and Genomics Unit, Office of the Clinical Director, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, 10 Center Drive, 12N248A, Building 10, MSC1560, Bethesda, MD 20852, USA; Michael.Ombrello{at}nih.gov
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Citation

Ombrello MJ, Arthur VL, Remmers EF, et al
Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications
Annals of the Rheumatic Diseases 2017;76:906-913.

Publication history

  • Received August 5, 2016
  • Revised October 27, 2016
  • Accepted November 12, 2016
  • First published December 7, 2016.
Online issue publication 
October 31, 2019

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/