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  • Should 2016 Criteria for Macrophage Activation Syndrome be applied in children with Kawasaki disease, as well as with systemic-onset juvenile idiopathic arthritis?

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Correspondence
Should 2016 Criteria for Macrophage Activation Syndrome be applied in children with Kawasaki disease, as well as with systemic-onset juvenile idiopathic arthritis?
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  1. Seung-Beom Han,
  2. Soo-Young Lee,
  3. Dae-Chul Jeong,
  4. Jin-Han Kang
  1. Department of Pediatrics, The Catholic University of Korea, Seoul, Korea
  1. Correspondence to Professor Soo-Young Lee, Department of Pediatrics, Incheon St. Mary's Hospital, The Catholic University of Korea, 56, Dongsu-ro, Bupyeong-gu, Incheon, 21431, Korea; sylee{at}catholic.ac.kr

https://doi.org/10.1136/annrheumdis-2016-209395

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    We read with deep interest the paper by Ravelli et al,1 who developed new criteria for the classification of macrophage activation syndrome (MAS) in patients with systemic-onset juvenile idiopathic arthritis (So-JIA). The hemophagocytic lymphohistiocytosis (HLH) diagnostic guidelines2 have been successfully used in the management of primary HLH, but there have been several limitations to their use in secondary HLH or MAS complicating systemic inflammatory disorders including So-JIA.3 ,4 In practice, the new …

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