Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

Zhuang Cui; Janet Crane; Hui Xie; Xin Jin; Gehua Zhen; Changjun Li; Liang Xie; Long Wang; Qin Bian; Tao Qiu; Mei Wan; Min Xie; Sheng Ding; Bin Yu; Xu Cao

doi:10.1136/annrheumdis-2015-207923

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Basic and translational research

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Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

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Zhuang Cui Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China PubMed articles Google scholar articles
Janet Crane Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Hui Xie Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Xin Jin Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Gehua Zhen Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Changjun Li Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Liang Xie Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Long Wang Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Qin Bian Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Tao Qiu Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Mei Wan Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles
Min Xie Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Sheng Ding Department of Pharmaceutical Chemistry, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Bin Yu Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China PubMed articles Google scholar articles
Xu Cao Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA PubMed articles Google scholar articles

Correspondence to Professor Xu Cao, Department of Orthopaedic Surgery, Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD 21205, USA; xcao11{at}jhmi.edu and Bin Yu; yubinol{at}163.com

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Cui Z, Crane J, Xie H, et al

Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

Annals of the Rheumatic Diseases 2016;75:1714-1721.

Publication history

Received May 14, 2015
Revised September 1, 2015
Accepted September 20, 2015
First published October 15, 2015.

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November 02, 2019

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