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Response to: ‘Does it make sense to investigate whether the offspring of people with a total knee replacement for severe primary knee osteoarthritis have a higher risk of worsening knee pain?’ by Lei et al
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We would like to thank Lei et al1 for their interest in and comments on our paper on the higher risk of worsening knee pain in the offspring with a family history of knee osteoarthritis (OA) as compared with control with no family history.2
First, we agree that the correlation between the radiographic OA and the presence of pain is weak and not significant in this cohort. Our group has published much of the research on this area and what does contribute to pain. Our contention is that radiographic OA is of limited significance and papers from this cohort show that. The MRI scans show many structural changes within the knee long before radiographic OA develops and these are …