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In their letter, Van Steenbergen and colleagues present data on the radiographic progression in rheumatoid arthritis (RA) patients stratified for anti-citrullinated protein antibody (ACPA) and rheumatoid factors (RFs) in two different patient cohorts.1 They show that the presence of ACPA is associated with a more pronounced progression of structural damage when scoring conventional radiographs by the standardised Sharp–van der Heijde method.1 These findings (i) underline previous radiographic findings that ACPAs are associated with radiographic progression in RA,2 (ii) stay in line with the known pathophysiologic function …
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.