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We read with interest the study conducted by Truchetet et al on the regulation of prostaglandin I2 (PGI2) in Th17 cell differentiation in systemic sclerosis (SSc). Actually, previous in vitro studies have found that synthetic PGI2 enhanced Th17 cell differentiation.1 Zhou et al2 have also demonstrated that PGI2 induced Th17 cell differentiation through modulating the ratio of interleukin 23 (IL-23)/interleukin 12 in a mouse model of experimental autoimmune encephalitis. However, in this study, Truchetet et al3 treated SSc-related digital ulcers with iloprost, providing evidence for the first time that iloprost increases the frequency of Th17 cells in human …
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