Article Text

other Versions

Evidence of association of the NLRP1 gene with giant cell arteritis
  1. Aurora Serrano1,
  2. F David Carmona1,
  3. Santos Castañeda2,
  4. Roser Solans3,
  5. José Hernández-Rodríguez4,
  6. María C Cid4,
  7. Sergio Prieto-González4,
  8. José A Miranda-Filloy5,
  9. Luis Rodríguez-Rodríguez6,
  10. Inmaculada C Morado6,
  11. Carmen Gomez-Vaquero7,
  12. Ricardo Blanco8,
  13. Bernardo Sopeña9,
  14. Norberto Ortego-Centeno10,
  15. Ainhoa Unzurrunzaga11,
  16. Begoña Marí-Alfonso12,
  17. Julio Sánchez-Martín13,
  18. María Jesús García-Villanueva14,
  19. Ana Hidalgo-Conde15,
  20. Giulia Pazzola16,
  21. Luigi Boiardi16,
  22. Carlo Salvarani16,
  23. Miguel A González-Gay8,
  24. Javier Martín1
  1. 1 Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain
  2. 2Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid, Spain
  3. 3Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain
  4. 4Vasculitis Research Unit, Department of Autoimmune and Systemic Diseases, Hospital Clínic, University of Barcelona, (IDIBAPS), Barcelona, Spain
  5. 5Department of Rheumatology, Hospital Xeral-Calde, Lugo, Spain
  6. 6Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain
  7. 7Department of Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
  8. 8Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Cantabria, Spain
  9. 9Thrombosis and Vasculitis Unit-Internal Medicine Department, Complejo Hospitalario Universitario de Vigo, Vigo, Spain
  10. 10Department of Internal Medicine, Hospital Clínico San Cecilio, Granada, Spain
  11. 11Department of Internal Medicine, Hospital de Galdakano, Vizcaya, Spain
  12. 12Department of Internal Medicine, Corporació Sanitaria Parc Taulí, Instituto Universitario Parc Taulí, UAB, Sabadell, Barcelona, Spain
  13. 13Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain
  14. 14Department of Rheumatology, Hospital Ramón y Cajal, Madrid, Spain
  15. 15Department of Internal Medicine, Hospital Universitario Virgen de la Victoria, Málaga, Spain
  16. 16Unita` Operativa di Reumatologia, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy
  1. Correspondence to Dr Javier Martin, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Consejo Superior de Investigaciones Científicas, Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento s/n, Armilla (Granada) 18100, Spain; martin{at}

Statistics from

Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity.1–3 NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation.4 In this study, we examined for the first time whether NLRP1 is associated with giant cell arteritis (GCA), a chronic systemic vasculitis affecting large and medium-sized arteries derived from the aorta, in particular the cranial branches of the carotid artery. GCA is the most common vasculitis in the elderly in Western countries with a female predominance.5 To investigate the possible genetic association of NLRP1 with this disease, we genotyped a single-nucleotide polymorphism (rs8182352), which has been reported to confer risk to the development of autoimmune processes in previous studies,1 ,2 in a total of 3583 individuals, comprising a discovery set from Spain (574 patients diagnosed with biopsy-proven GCA and 2366 healthy controls) and a replication set of subjects from Italy (111 biopsy-proven GCA patients and 532 controls) using a predesigned TaqMan allele discrimination assay. All individuals were of …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.