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Due to the well-established risk of latent tuberculosis infection (LTBI) reactivation, and its potentially devastating consequences in patients treated with tumour necrosis factor (TNF)-α inhibitors (anti-TNF), a low threshold for TB chemoprophylaxis is usually recommended.1 ,2 Conversely, TB chemoprophylaxis is time consuming, delays the initiation of required treatment, adds to the overall cost of treatment, and carries risk of adverse events in its own right.3 A screening algorithm able to safely reduce the frequency of TB chemoprophylaxis would be of great value.
Recently, Mariette et al4 showed that replacing the tuberculin skin test (TST) with interferon-γ release assays in their LTBI screening algorithm reduced the requirement for TB chemoprophylaxis from 45.2% to 27.3%, while there were no new cases of TB …
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