You are here

  • Home
  • Online First
  • The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study

Article Text

Article menu

other Versions

Download PDFPDF
Clinical and epidemiological research
Concise report
The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study
  1. Ida Kristin Haugen1,
  2. David T Felson2,
  3. Martin Englund2,3,
  4. Ke Wang2,
  5. Piran Aliabadi4,
  6. Ali Guermazi5,
  7. Frank W Roemer5,6,
  8. Tuhina Neogi2
  1. 1Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
  2. 2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA
  3. 3Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
  4. 4Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
  5. 5Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA
  6. 6Department of Radiology, Klinikum Augsburg, Augsburg, Germany
  1. Correspondence to Dr Ida K. Haugen, Department of Rheumatology, Diakonhjemmet Hospital, P.O. Box 23, Vinderen, Oslo 0319, Norway; haugen_ida{at}hotmail.com

Abstract

Objective To examine whether erosive hand osteoarthritis (OA) is associated with knee subchondral bone attrition (SBA) and systemic bone mineral density (BMD).

Methods Associations of MRI-defined knee SBA with radiographic erosive hand OA were evaluated in 1253 Framingham participants using logistic regression with generalised estimating equations. We also examined the association between the number of erosive OA finger joints and SBA adjusted for the number of non-erosive OA finger joints. Associations between erosive hand OA and femoral neck BMD were explored in 2236 participants with linear regression. Analyses were adjusted for age, sex and body mass index.

Results Participants with erosive hand OA had increased odds of knee SBA (OR=1.60, 95% CI 1.07 to 2.38). The relation between the number of erosive OA finger joints and SBA became non-significant when adjusted for the number of non-erosive OA joints as a proxy for the burden of disease. There was a non-significant trend towards higher BMD in erosive hand OA compared with participants without hand OA.

Conclusions Erosive hand OA was associated with knee SBA, but the relation might be best explained by a heightened burden of disease. No significant relation of erosive hand OA with BMD was found.

https://doi.org/10.1136/annrheumdis-2012-201659

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Funding Supported by grants from the National Institutes of Health (AG18393, AR47785, AR055127), the Swedish Research Council, the Faculty of Medicine at Lund University, the OARSI scholarship and South-Eastern Norway Regional Health Authority.

    • Competing interests F Roemer is a shareholder in Boston Imaging Core Lab (BICL) and a consultant to Merck-Serono and NIH. A Guermazi is a shareholder in BICL and a consultant to Merck-Serono, Novartis, Genzyme, AstraZeneca and Stryker.

    • Patient consent Obtained.

    • Ethics approval Ethics approval provided by the Boston University Medical Center Institutional Review Board.

    • Provenance and peer review Not commissioned; externally peer reviewed.