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The diagnosis of rheumatoid arthritis (RA) is based on classification criteria set by the 2010 RA classification criteria including serological assessment of rheumatoid factor (RF) and anticitrulline-containing protein/peptide (anti-CCP) antibody.1 2 Anti-CCP antibody is specific (94–99%) for RA; however, 25% of patients with established RA and 40% of patients with early RA are negative for this marker.3 4 Novel biomarkers, especially for early RA and/or for RA lacking RF and anti-CCP antibody markers (ie, seronegative RA) are therefore urgently required. Circulating immune complexes (CICs) present in the human body are likely to contain many different antigens that may reflect underlying disease, so antigens incorporated into CICs are promising candidates for diagnostic biomarkers. We developed a novel proteomic strategy (immune complexome analysis) to identify and profile antigens in CICs and …
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