Article Text
Abstract
Objective Identify serum biomarkers modulated by golimumab treatment and associated with clinical response in patients with ankylosing spondylitis (AS).
Methods Sera were collected at weeks 0, 4 and 14 from 100 patients with active AS in the GO–RAISE study. Patients were randomly assigned subcutaneous injections of placebo, golimumab 50 mg, or golimumab 100 mg every 4 weeks. Samples were tested for select inflammatory, bone and cartilage markers, and protein profiling was also performed.
Results Golimumab treatment resulted in significant decreases in several serum proteins at weeks 4 and 14 compared with placebo. Patients who achieved clinical response at week 14, as assessed by a ≥20% improvement in the Assessment in SpondyloArthitis international Society response criteria (ASAS 20), demonstrated a distinct biomarker profile with lower levels of acute phase reactants and inflammatory biomarkers compared with patients who did not. Notably, combinations of two or three biomarkers assessed at baseline were predictive of various clinical outcomes (ASAS 20, Bath ankylosing spondylitis disease activity index 50 or Bath ankylosing spondylitis functional index) using a logistic regression analysis, and the overall predictive values for these combined biomarkers were greater than observed for C-reactive protein (CRP) alone.
Conclusion Golimumab modulated acute phase reactants and inflammatory markers in patients with active AS. Specific combinations of biomarkers at baseline demonstrated a stronger prediction for clinical efficacy than CRP alone. These data provide insights into the mechanism of golimumab on inflammatory processes driving AS pathology, and may have utility in managing the treatment of patients with AS.
This paper is freely available online under the BMJ Journals unlocked scheme, see http://ard.bmj.com/info/unlocked.dtl
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Footnotes
↵* Currently of Hoffman-La Roche
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Funding This study was funded by Centocor Research and Development, Inc. and Schering-Plough Research Institute, Inc. A division of Johnson & Johnson Pharmaceutical Research & Development, LLC.
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Competing interests JB has received consultancy fees, speaking fees and/or honoraria (less than US$10 000 each) from Centocor, Schering-Plough, Wyeth, Amgen, Abbott, Bristol-Myers Squibb, UCB, Roche, Chugai, Pfizer and MSD. DvdH has received consulting fees and/or research grants from Abbott, Amgen, AstraZeneca, BMS, Centocor, Chugai, Eli-Lilly, GSK, Merck, Novartis, Osuka, Pfizer, Roche, Sanofi-Aventis, Schering-Plough, UCB and Wyeth. AD has received payments for educational lectures, teleconferences and serving on advisory boards for Centocor, a company that may have a commercial interest in the results of this research. This potential conflict of interest has been reviewed and managed by OHSU. ME has nothing to declare. RDI has served as a consultant to Merck, Schering-Plough, Abbott, Sanofi-Aventis, Amgen-Wyeth and Pfizer. MM, BH, SV and CW were all employees of Johnson & Johnson at the time of the study and own Johnson & Johnson stock and/or stock options.
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Patient consent Obtained.
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Ethics approval The protocol was reviewed and approved by the institutional review board or independent ethics committee at each site.
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Provenance and peer review Not commissioned; externally peer reviewed.