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Cumulative evidence indicates that the BCL2-antagonist/killer 1 (BAK1) gene could be involved in several autoimmune diseases.1 2 The proapoptotic BCL2 family members BAX and BAK are essential for regulating the number of B and T cells.2,–,4 A recent study in a Colombian population suggested that the BAK1 rs513349 and rs5745582 single nucleotide polymorphisms (SNPs) as well as the haplotype rs513349G-rs561276C-rs5745582A are significantly associated with autoimmune rheumatic diseases.1 The aim of the present study was to evaluate the influence …
Funding This work was partially supported by RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), within the VI PN de I+D+i 2008–2011 (FEDER). L-MD-G was supported by the ‘Ayudas Predoctorales de Formación en Investigación en Salud (PFIS—FI09/00544)’ from the ‘Instituto de Salud Carlos III’.
Competing interests None.
Ethics approval The study was approved by the local ethical committees of all participating centres.
Provenance and peer review Not commissioned; externally peer reviewed.
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