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Rheumatoid arthritis (RA) and osteoarthritis (OA) are two of the most frequent articular diseases. Recently, adipokines have been proposed as relevant mediators of cartilage degeneration in both OA and RA.1 Our group has previously demonstrated that RA patients have elevated serum levels of leptin and adiponectin,2 while others have shown positive associations between serum levels of leptin and hip-radiographic OA,3 and of adiponectin and erosive OA.4 Thus, several studies have suggested that adipokines can modulate the …
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