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Adiponectin and leptin increase IL-8 production in human chondrocytes
  1. Rodolfo Gómez1,
  2. Morena Scotece1,
  3. Javier Conde1,
  4. Juan J Gómez-Reino1,
  5. Francisca Lago2,
  6. Oreste Gualillo1
  1. 1SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela, Spain
  2. 2SERGAS, Research Laboratory 7, Molecular and Cellular Cardiology, Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Santiago de Compostela, Spain
  1. Correspondence to Dr Oreste Gualillo, SERGAS, Research Laboratory 9, NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Institute of Medical Research (IDIS), Santiago University Clinical Hospital, Travesia Choupana s/n, Building C, Level -2, Santiago de Compostela 15706, Spain; oreste.gualillo{at}sergas.es

https://doi.org/10.1136/ard.2010.145672

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    Rheumatoid arthritis (RA) and osteoarthritis (OA) are two of the most frequent articular diseases. Recently, adipokines have been proposed as relevant mediators of cartilage degeneration in both OA and RA.1 Our group has previously demonstrated that RA patients have elevated serum levels of leptin and adiponectin,2 while others have shown positive associations between serum levels of leptin and hip-radiographic OA,3 and of adiponectin and erosive OA.4 Thus, several studies have suggested that adipokines can modulate the …

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    Footnotes

    • Funding The work of OG and FL is funded by Instituto de Salud Carlos III and Xunta de Galicia (SERGAS) through a research-staff stabilisation contract. They are supported by Instituto de Salud Carlos III and Xunta de Galicia (OG grants: PI08/0040 and PGIDIT07PXIB918090PR; FL grants: PI060919, PI08/0044 and PGIDIT06PXIB918307PR). This work was also partially supported by the RETICS Programme, RD08/0075 (RIER) and REDINSCOR via Instituto de Salud Carlos III (ISCIII), within the VI NP of R+D+I 2008–2011.

    • Competing interests None.

    • Ethics approval This study was conducted with the approval of the Santiago University Clinical Hospital Ethics Committee.

    • Provenance and peer review Not commissioned; externally peer reviewed.