Article Text

other Versions

Download PDFPDF
Extended report
Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study
  1. S M M Verstappen1,
  2. M F Bakker1,
  3. A H M Heurkens2,
  4. M J van der Veen3,
  5. A A Kruize1,
  6. M A W Geurts4,
  7. J W J Bijlsma1,
  8. J W G Jacobs1
  1. 1University Medical Center Utrecht, Utrecht, The Netherlands
  2. 2Meander Medical Centre, Amersfoort, The Netherlands
  3. 3St Jansdal Hospital, Harderwijk, The Netherlands
  4. 4St Antonius Hospital, Nieuwegein, The Netherlands
  1. Correspondence to Dr J W G Jacobs, University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02.127, PO Box 85500, 3508 GA Utrecht, The Netherlands; j.w.g.jacobs{at}


Objective To evaluate toxicity profiles in patients with rheumatoid arthritis (RA) treated either according to an intensive or a conventional treatment strategy approach with methotrexate (MTX) and to study factors associated with MTX-related toxicity.

Methods Data were used from the Computer-Assisted Management in Early Rheumatoid Arthritis (CAMERA) study, in which clinical efficacy of an intensive treatment strategy with MTX was more beneficial than a conventional treatment strategy approach. In this study, data on adverse events (AEs) were compared between the two strategy groups. Logistic regression analyses were used to identify possible associations between factors assessed at baseline and withdrawal due to MTX-related AEs or liver toxicity at follow-up.

Results Although significantly more patients in the intensive strategy group experienced MTX-related AEs than in the conventional strategy group, all recorded AEs were relatively mild. A higher body mass index (BMI) was significantly associated with withdrawal due to MTX-related AEs in the multiple regression analyses (odds ratio=1.207, 95% confidence interval 1.02 to 1.44, p=0.033). There was a trend towards an association between diminished creatinine clearance and MTX withdrawal. For liver toxicity, increased serum liver enzymes at baseline were associated with liver toxicity during follow-up.

Conclusion Although the occurrence of AEs in the intensive strategy group was higher than in the conventional strategy group, the previously observed clinical efficacy of an intensive treatment strategy seems to outweigh the observed toxicity profiles. When starting MTX, attention should be given to patients with a high BMI and those with increased levels of liver enzymes and decreased renal function.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the medical ethical committees of all participating hospitals.

  • Provenance and peer review Not commissioned; externally peer reviewed.