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HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis
  1. Yukinori Okada1,*,
  2. Akari Suzuki2,
  3. Ryo Yamada3,
  4. Yuta Kochi2,
  5. Kenichi Shimane2,
  6. Keiko Myouzen2,
  7. Michiaki Kubo2,
  8. Yusuke Nakamura3,
  9. Kazuhiko Yamamoto1
  1. 1 The University of Tokyo, Japan;
  2. 2 Institute of Physical and Chemical Research (RIKEN), Japan;
  3. 3 Institute of Medical Science, the University of Tokyo, Japan
  1. Correspondence to: Yukinori Okada, Department of Allergy and Rheumatology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; yokada-tky{at}


Anti-cyclic citrullinated peptide (anti-CCP) antibody is a highly specific biomarker for Rheumatoid Arthritis (RA), and recognized as a predictor of development of RA.[1,2] It had been demonstrated that some HLA-DRB1 alleles, such as shared epitope (SE) alleles, significantly contribute to the positivity of anti-CCP antibody and the susceptibility of anti-CCP antibody-positive RA.[3,4] However, the quantitative effect of HLA-DRB1 alleles on anti-CCP antibody levels in RA patients is controversial.[3,5,6] Therefore, we carried out a large-scale study to study the quantitative effects of HLA-DRB1 alleles on anti-CCP antibody levels in Japanese patients with RA.

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