Objective: To evaluate the impact of TNFα blockers on the presence of liver fibrosis in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with methotrexate (MTX).
Methods: Subjects were consecutive patients with RA and PsA who had undergone MTX treatment for at least one year +/- TNF blockade for over 6 months. Liver fibrosis was assessed using non-invasive transient elastography (FibroScan). Regression models were used to compare FibroScan values of RA and PsA patients receiving TNFα blockers with those who were not.
Results: FibroScan assessments were performed on 51 RA and 43 PsA patients. Compared to RA patients, those with PsA were predominantly young males, received lower cumulative dosages of MTX and exhibited a higher incidence of liver steatosis and hyperlipidemia. An abnormal result was observed in 7.1% of the anti-TNFα-naïve and in 13% of the anti-TNFα-treated patients in the RA group, and in 30% of the anti-TNFα-naïve and 4.3% of the anti-TNFα-treated patients in the PsA group (OR = 0.11, 95% CI 0.02 to 0.98). Results of the PsA group were robust when adjusted for baseline characteristics.
Conclusion: The results suggest a protective effect of TNFα inhibitors against the development of liver fibrosis in patients with PsA.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.