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Anti-modified citrullinated vimentin (MCV) antibodies in patients with very early synovitis
  1. Karim Raza1,*,
  2. Linda Mathsson2,
  3. Christopher D Buckley1,
  4. Andrew Filer1,
  5. Johan Rönnelid2
  1. 1 University of Birmingham, United Kingdom;
  2. 2 Uppsala University, Sweden
  1. Correspondence to: Karim Raza, Division of Immunity and Infection, University of Birmingham, Rheumatology Research Group, Division of Immunity and Infection, University of Birmingham, Birmingham, B15 2TT, United Kingdom; k.raza{at}


Anti-CCP antibodies are very specific for the development of RA in patients with very early synovitis.[1] Their predictive value is underscored by their high weighting in an algorithm validated in patients with undifferentiated synovitis ≤ 3 months duration.[2] However, using this algorithm, one cannot accurately predict outcome in 25% of patients and additional predictive markers are needed. We have reported that antibodies against type II collagen were unhelpful in this phase of disease.[3] Several groups have measured anti-modified citrullinated vimentin (MCV) antibodies in RA patients. In patients with symptoms of < 12 months’ duration, the specificity and sensitivity of anti-MCV were 95% and 71% respectively.[4] The enhanced sensitivity, compared with anti-CCP2, raised the possibility of clinical utility. Subsequently, in patients with synovitis of < 2 years duration, a specificity and sensitivity of 83% and 62% (vs 93% and 57% for anti-CCP2 respectively) has been reported [5].

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