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The safety of anti-Tumor Necrosis Factor treatments in rheumatoid arthritis: meta and exposure adjusted pooled analyses of serious adverse events
  1. John Paul Leombruno (john.leombruno{at}
  1. Department of Pharmaceutical Sciences Pharmacoepidemiology, Canada
    1. Thomas R. Einarson (t.einarson{at}
    1. Department of Pharmaceutical Sciences Pharmacoepidemiology, Canada
      1. Edward C Keystone (ksnow{at}
      1. University of Toronto. Mount Sinai Hospital, Canada


        Objective: To evaluate the safety of biologic treatments for rheumatoid arthritis (RA) using results from randomized controlled trials (RCTs).

        Methods: We searched the literature to December 2007 for RCTs evaluating inhibitors of tumour necrosis factor alpha (anti-TNFs) for RA. Safety data was abstracted and risk estimates were calculated using three approaches, meta-analysis with and without adjustment for exposure and simple exposure adjusted pooling.

        Results: Eighteen randomized trials involving 8,808 RA subjects were included. Treatment with recommended doses of anti-TNFs found no increase in the odds of death (OR=1.39, 95%CI 0.74-2.62), serious adverse events (OR=1.11; 95%CI 0.94-1.32), serious infection (OR=1.21; 95%CI 0.89-1.63), lymphoma (OR=1.26; 95%CI 0.52-3.06), non-melanoma skin cancers (OR=1.27; 95%CI 0.67-2.42) or the composite endpoint of non-cutaneous cancers plus melanomas (OR=1.31; 95%CI 0.69-2.48) when evaluated using the unadjusted meta-analytic method. Risk estimates were similar with the other methods. For subjects who received two to three times the recommended doses of anti-TNF the risk of serious infection was increased with the unadjusted meta-analytic and pooled analysis; 2.07 (95%CI:1.31-3.26) and 1.83 (95%CI:1.18-2.85) respectively but not increased in the exposure adjusted meta-analysis 1.99 (95%CI:0.90-4.37). Meta-regression identified that the risk of serious infection with anti-TNF therapy decreases with increasing trial duration (p=0.035).

        Conclusion: Meta-analytic and exposure adjusted pooled analyses on over 8,800 RA subjects in RCTs treated over an average of 0.8 years did not identify an increased risk of serious adverse events with recommended doses. High dose anti-TNF therapy was associated with a twofold increase in the risk of serious infections.

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