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Pathological features of temporal arteries in patients with giant cell arteritis presenting with permanent visual loss.
  1. D Chatelain (chatelain.denis{at}
  1. CHU Nord, France
    1. P Duhaut (duhaut.pierre{at}
    1. CHU Nord, Amiens, France
      1. J Schmidt (schmidt.jean{at}
      1. CHU Amiens, France
        1. R Loire (laurent.pinede{at}
        1. Claude Bernard University, Lyon, France
          1. S Bosshard (bosshard{at}
          1. Claude Bernard University, Lyon, France
            1. M Guernou (guernou.malika{at}
            1. CHU Nord, Amiens, France
              1. H Pellet (hpellet{at}
              1. Claude Bernard University, Lyon, France
                1. J-C Piette (jean-charles.piette{at}
                1. Pitié-Salpêtrière Hospital, Paris, France
                  1. H Sevestre (sevestre.henri{at}
                  1. CHU Nord, Amiens, France
                    1. J-P Ducroix (ducroix.jean-pierre{at}
                    1. CHU Nord, Amiens, France


                      Background: Permanent visual loss (PVL) is the most dreaded complications of giant cell arteritis (GCA), and its risk factors are still unclear.

                      Objectives: The aim of our study was to assess the pathological features predictive of PVL on temporal artery biopsy (TAB) specimens in GCA patients.

                      Methods: The slides of 391 TAB specimens from GCA patients were reviewed by two pathologists without clinical information.

                      Results: Twenty nine patients (26 females and 3 males, mean age 78.3 years) presented with unilateral PVL at the onset of the disease, and 362 patients (258 females, 104 males, mean age 74.7 years), did not. The pathological features strongly predictive of PVL were the presence (p=0.0025), number (p=0.001) and aggregates of giant cells (p=0.001), presence of plasmocytes (p=0.002), thickened intima (p=0.007), neoangiogenesis (p=0.001) and degree of arterial occlusion (p=0.0058). Presence of neutrophils, eosinophils, parietal necrosis, calcification in the arterial wall, disruption of the internal elastic membrane were similar in both groups. Total obstruction of the arterial lumen by a thrombus, intensity of the inflammatory cells infiltration, inflammation of small vessels, nerves and veins surrounding the temporal artery were not associated with blindness. In multivariate analysis, only giant cells remained significantly associated with PVL.

                      Conclusion: Giant cells are strongly associated with PVL, with a significant gradient between great risk and large number of giant cells.. However, PVL was neither associated with the intensity of the inflammatory infiltrate, nor with the presence of arterial thrombosis.

                      • blindness risk
                      • giant cell arteritis
                      • pathological features
                      • prospective cohort

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