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HLA-DR11 and HLA-DR2 are negatively associated with autoantibody production in chronic hepatitis C
  1. C-Y Hu1,*,
  2. C-S Wu2,*,
  3. C-S Lee3,
  4. C-H Wu2,
  5. H-F Tsai4,
  6. P-J Chen2,
  7. P-N Hsu2,5
  1. 1Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
  2. 2Department of Internal Medicine, National Taiwan University Hospital, Taiwan
  3. 3Department of Internal Medicine, McKay Memorial Hospital and MacKay Medicine, Nursing and Management College, Taiwan, and Taipei Medical University, Taipei, Taiwan
  4. 4Department of Internal Medicine, Taipei City Hospital, Ho-Ping Branch, Taipei, Taiwan
  5. 5Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
  1. Correspondence to:
    Professor P-N Hsu
    Graduate Institute of Immunology, College of Medicine, National Taiwan University, No 1, Sec. 1, Jen-Ai Rd, Taipei, Taiwan, Republic of China; phsu{at}ha.mc.ntu.edu.tw

https://doi.org/10.1136/ard.2005.039982

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    Chronic hepatitis C virus (HCV) infection is associated with immunological abnormality, including circulating immune complexes, production of autoantibodies, and concurrent autoimmune disorders.1,2 Both viral and host factors may contribute to the development of autoantibodies and rheumatological manifestations. In this study we investigated the production of autoantibodies in patients with HCV in order to determine a possible link between the polymorphic HLA-DRB1 allele(s) and autoantibody production in chronic HCV infection.

    We analysed HLA-DR polymorphisms in 288 HCV infected subjects in the Department of Internal Medicine, National Taiwan University Hospital. All patients were assayed for their serum autoantibodies with detection of antinuclear antibodies (ANA), rheumatoid factor (RF), antithyroid antibodies (antithyroglobulin (ATG) and antimicrosomal (AMG) antibodies), and antineutrophil cytoplasmic antibodies (ANCA). The HLA-DR polymorphisms were genotyped by polymerase chain reaction and sequence-specific …

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    Footnotes

    • ↵* C-Y Hu and C-S Wu contributed equally to this work.

    • Supported by grants from the National Science Council (NSC 91-2320B-002, and NSC91-2314-B-002-278)