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  • Response to: Correspondence on “HLA-DR ‘naturally’ presented peptides: you will find what you have pulsed with” by Roudier

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Correspondence response
Response to: Correspondence on “HLA-DR ‘naturally’ presented peptides: you will find what you have pulsed with” by Roudier
  1. Diego Catalan1,
  2. Dolores Jaraquemada2,
  3. Juan C Aguillón1
  1. 1 Immune Regulation and Tolerance Research Group, Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
  2. 2 Immunology Unit, Cell Biology, Physiology and Immunology Department, Institut de Biotecnologia i Biomedicina, Universitat de Barcelona, Barcelona, Spain
  1. Correspondence to Dr Juan C Aguillón, Immune Regulation and Tolerance Research Group, Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédicas (ICBM), Universidad de Chile Facultad de Medicina, Santiago, Chile; jaguillo{at}med.uchile.cl; Dr Diego Catalan; dfcatalan{at}med.uchile.cl

https://doi.org/10.1136/annrheumdis-2022-222758

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    We appreciate Dr Roudier’s interest and comment on our recent article.1 2 The aim of our study was to analyse the human leukocyte antigen (HLA)-DR-associated peptidome of synovial tissue (ST) and of dendritic cells (DCs) pulsed with synovial fluid (SF) or ST, to identify epitopes that trigger T cell responses in patients with rheumatoid arthritis (RA). Dr Roudier is indeed correct when he asserts that our study is biased toward the synovium. However, we consider that ours is not a ‘conception bias’ but a deliberate effort to focus our attention on a particular tissue as a source of autoantigens, incidentally the main target of the inflammatory response in RA.

    It is far from our intention to claim that only synovial antigens are relevant in driving RA autoimmune responses. Our hypothesis assumes, instead, that …

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    Footnotes

    • Handling editor Josef S Smolen

    • Twitter @jcaguillo

    • Contributors DC, DJ and JCA participated in drafting the response letter.

    • Funding This research was funded by Fondecyt-ANID-Chile (grant number: 1181853).

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.

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