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Correspondence on “Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis”
  1. Jean Roudier1,2
  1. 1 Autoimmune arthritis, INSERM UMRs1097, Aix Marseilles University, Marseille, France
  2. 2 Rheumatology, APHM/IML, Marseilles, France
  1. Correspondence to Professor Jean Roudier, Immunogenetics of RA, INSERM UMRs 1097, 13288 Marseille cedex 9, France; jean.roudier{at}

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The article titled ‘Isolation of HLA-DR naturally presented peptides identifies T cell epitopes for rheumatoid arthritis’ reports the elution and characterisation by mass spectrometry of ‘naturally processed’ peptides from the synovial fluid and synovium of patients with rheumatoid arthritis.1

It uses state of the art technology to produce monocyte-derived dendritic cells and analyse the peptides associated with their Human Leucocyte Antigen DR molecules by mass spectrometry. However, the whole project is based on the a priori hypothesis that RA develops …

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  • Handling editor Josef S Smolen

  • Contributors This letter is a short criticism of a recently published article.

  • Funding This study was funded by Institut National de la Santé et de la Recherche Médicale (UMRs1097).

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Provenance and peer review Commissioned; internally peer reviewed.

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