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In their letter,1 Drs Bossuyt and Meroni have used an elegant and creative approach to make use of the data on antinuclear antibodies (ANAs) of the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria project for systemic lupus erythematosus (SLE) .2 They point out that the individual ANA titre has implications for the likelihood ratio (LR) of a diagnosis of SLE. This interpretation concludes that the LR for 1:160 is just below 1 (0.94) and …
Handling editor David S Pisetsky
Contributors All authors composed the draft response together and agreed on the submitted version.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.
Provenance and peer review Commissioned; internally peer reviewed.