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Response to: Correspondence on “European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance” by Bossuyt et al
  1. Martin Aringer1,
  2. Karen Costenbader2,
  3. Nicolai Leuchten1,
  4. Thomas Dörner3,
  5. Sindhu R Johnson4
  1. 1 Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine Carl Gustav Carus at the TU Dresden, Dresden, Germany
  2. 2 Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, USA
  3. 3 Department of Medicine/Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
  4. 4 Department of Medicine, Toronto Western Hospital, University Health Network, Mount Sinai Hospital, University of Toronto, Toronto Scleroderma Research Program, Toronto, Ontario, Canada
  1. Correspondence to Professor Martin Aringer, Internal Medicine III, TU Dresden, 01062 Dresden, Germany; martin.aringer{at}

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In their letter,1 Drs Bossuyt and Meroni have used an elegant and creative approach to make use of the data on antinuclear antibodies (ANAs) of the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria project for systemic lupus erythematosus (SLE) .2 They point out that the individual ANA titre has implications for the likelihood ratio (LR) of a diagnosis of SLE. This interpretation concludes that the LR for 1:160 is just below 1 (0.94) and …

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  • Handling editor David S Pisetsky

  • Contributors All authors composed the draft response together and agreed on the submitted version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

  • Provenance and peer review Commissioned; internally peer reviewed.

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