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  • Correspondence on ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study’

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Correspondence
Correspondence on ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study’
  1. Timothée Klopfenstein1,
  2. Vincent Gendrin1,
  3. Thierry Conrozier2,
  4. Aurélie Gerazime3,
  5. Marc Puyraveau3,
  6. Souheil Zayet1
  1. 1 Infectious Disease Department, North Franche-Comté Hospital, Montbeliard, France
  2. 2 Rheumatology Department, North Franche-Comté Hospital, Montbeliard, France
  3. 3 Methodology unit, Clinical Investigation Center INSERM 1431, CHU Besancon, Besancon, France
  1. Correspondence to Dr Timothée Klopfenstein, Infectious Disease Department, North Franche-Comté Hospital, 25209 Montbeliard, France; timothee.klopfenstein{at}hnfc.fr

https://doi.org/10.1136/annrheumdis-2021-220771

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    We have read with great interest the study conducted by Ramiro et al 1 entitled ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study’. This study was among the first publications showing benefit of tocilizumab administration in patients with severe COVID-19-associated cytokine storm syndrome, in July 2020.1 In the same way, we observed a benefit of tocilizumab administration in a cohort of 206 patients during the first wave of the pandemic, in June 2020.2

    We have now more ‘evidence-based medicine’ to discuss tocilizumab’s place in COVID-19. Thus, nine randomised clinical trials (RCTs)3–11 have been published about tocilizumab administration in COVID-19; however, the effects on mortality remain heterogeneous in these trials.12 We recently made a …

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    Footnotes

    • Contributors TK, SZ and VG drafted the manuscript. AG and MP made the statistical analysis. All authors revised the final manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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