Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes

May Yee Choi; Irene Chen; Ann Elaine Clarke; Marvin J Fritzler; Katherine A Buhler; Murray Urowitz; John Hanly; Yvan St-Pierre; Caroline Gordon; Sang-Cheol Bae; Juanita Romero-Diaz; Jorge Sanchez-Guerrero; Sasha Bernatsky; Daniel J Wallace; David Alan Isenberg; Anisur Rahman; Joan T Merrill; Paul R Fortin; Dafna D Gladman; Ian N Bruce; Michelle Petri; Ellen M Ginzler; Mary Anne Dooley; Rosalind Ramsey-Goldman; Susan Manzi; Andreas Jönsen; Graciela S Alarcón; Ronald F van Vollenhoven; Cynthia Aranow; Meggan Mackay; Guillermo Ruiz-Irastorza; Sam Lim; Murat Inanc; Kenneth Kalunian; Søren Jacobsen; Christine Peschken; Diane L Kamen; Anca Askanase; Jill P Buyon; David Sontag; Karen H Costenbader

doi:10.1136/ard-2022-223808

Article info

Systemic lupus erythematosus

Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes

Authors

May Yee Choi Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada PubMed articles Google scholar articles
Irene Chen Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Ann Elaine Clarke Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada PubMed articles Google scholar articles
Marvin J Fritzler Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada PubMed articles Google scholar articles
Katherine A Buhler Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada PubMed articles Google scholar articles
Murray Urowitz Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Lupus Clinic, Toronto, Ontario, Canada PubMed articles Google scholar articles
John Hanly Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada PubMed articles Google scholar articles
Yvan St-Pierre Medicine, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada PubMed articles Google scholar articles
Caroline Gordon Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, Birmingham University Medical School, Birmingham, West Midlands, UK PubMed articles Google scholar articles
Sang-Cheol Bae Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Hanyang University Institute for Rheumatology and Hanyang University Institute of Bioscience and Biotechnology, Seoul, The Republic of Korea PubMed articles Google scholar articles
Juanita Romero-Diaz Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico PubMed articles Google scholar articles
Jorge Sanchez-Guerrero Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Sasha Bernatsky Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada PubMed articles Google scholar articles
Daniel J Wallace Division of Rheumatology, Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, California, USA PubMed articles Google scholar articles
David Alan Isenberg Centre for Rheumatology, Department of Medicine, University College London, London, UK PubMed articles Google scholar articles
Anisur Rahman Centre for Rheumatology, Department of Medicine, University College London, London, UK PubMed articles Google scholar articles
Joan T Merrill Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA PubMed articles Google scholar articles
Paul R Fortin Division of Rheumatology, CHU de Québec - Université Laval, Quebec City, Quebec, Canada PubMed articles Google scholar articles
Dafna D Gladman Center for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto, Lupus Clinic, Toronto, Ontario, Canada PubMed articles Google scholar articles
Ian N Bruce Epidemiology Unit, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Michelle Petri Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Ellen M Ginzler Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA PubMed articles Google scholar articles
Mary Anne Dooley Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA PubMed articles Google scholar articles
Rosalind Ramsey-Goldman Department of Medicine, Division of Rheumatology, Northwestern University and Feinberg School of Medicine, Chicago, Illinois, USA PubMed articles Google scholar articles
Susan Manzi Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA PubMed articles Google scholar articles
Andreas Jönsen Clinical Sciences, Lund University, Lund, Sweden PubMed articles Google scholar articles
Graciela S Alarcón Department of Medicine, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA PubMed articles Google scholar articles
Ronald F van Vollenhoven Rheumatology & Immunology Center, University of Amsterdam, Amsterdam, The Netherlands PubMed articles Google scholar articles
Cynthia Aranow Division of Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, Manhasset, New York, USA PubMed articles Google scholar articles
Meggan Mackay Division of Autoimmune and Musculoskeletal Disease, Feinstein Institute for Medical Research, Manhasset, New York, USA PubMed articles Google scholar articles
Guillermo Ruiz-Irastorza Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain PubMed articles Google scholar articles
Sam Lim Division of Rheumatology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Murat Inanc Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey PubMed articles Google scholar articles
Kenneth Kalunian Department of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, California, USA PubMed articles Google scholar articles
Søren Jacobsen Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark PubMed articles Google scholar articles
Christine Peschken Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada PubMed articles Google scholar articles
Diane L Kamen Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articles Google scholar articles
Anca Askanase Hospital for Joint Diseases, New York University, Seligman Centre for Advanced Therapeutics, New York, New York, USA PubMed articles Google scholar articles
Jill P Buyon Division of Rheumatology, New York University School of Medicine, New York, New York, USA PubMed articles Google scholar articles
David Sontag Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Karen H Costenbader Department of Medicine, Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, Massachusetts, USA Medicine, Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles

Correspondence to Dr May Yee Choi, University of Calgary Cumming School of Medicine, Calgary, AB T2N4N1, Canada; may.choi{at}ucalgary.ca

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Citation

Choi MY, Chen I, Clarke AE, et al

Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes

Annals of the Rheumatic Diseases 2023;82:927-936.

Publication history

Received December 21, 2022
Accepted April 6, 2023
First published April 21, 2023.

Online issue publication

June 12, 2023

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