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We read with great interest the article published by D’Silva et al.1 The authors reported three patients with inadequate antibody response to SARS-CoV-2 infection, two of whom received rituximab (RTX). Presence of antispike or antinucleocapsid IgG antibodies is strongly associated with reduced reinfection rates following the COVID-19.2 RTX is an anti-CD 20 monoclonal antibody that depletes B cells. Both T cell-dependent and T cell-independent immune responses against various infections agents are drastically reduced up to 6 months following RTX infusion.3 4 Here we report the antibody response to SARS-CoV-2 infection in five patients with autoimmune rheumatic disease on RTX therapy.
In our centre 224 patients with autoimmune rheumatic diseases had RT-PCR proven COVID-19 infection between March 2020 and December 2020. Of these, five patients had received RTX therapy within 18 …
Contributors Study concept and design: PS and SKC. Acquisition of the clinical and laboratory data: ARM, SS and SASB. Acquisition and interpretation of laboratory data: VS. Drafting and editing paper: PS, SKC and SA. Critical revision of the manuscript: PS and SA. All authors critically reviewed and approved the final manuscript for publication.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; internally peer reviewed.