Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage

Taotao Li; Changrong Ge; Alexander Krämer; Outi Sareila; Monica Leu Agelii; Linda Johansson; Kristina Forslind; Erik Lönnblom; Min Yang; Bingze Xu; Qixing Li; Lei Cheng; Göran Bergström; Gonzalo Fernandez; Alf Kastbom; Solbritt Rantapää-Dahlqvist; Inger Gjertsson; Rikard Holmdahl

doi:10.1136/ard-2022-223633

Article info

Rheumatoid arthritis

Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage

Authors

Taotao Li Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles
Changrong Ge Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles
Alexander Krämer Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles
Outi Sareila Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden Department of Rheumatology and Inflammation Research, University of Gothenburg Sahlgrenska Academy, Göteborg, Sweden PubMed articles Google scholar articles
Monica Leu Agelii Department of Rheumatology and Inflammation Research, University of Gothenburg Sahlgrenska Academy, Göteborg, Sweden PubMed articles Google scholar articles
Linda Johansson Department of Public Health and Clinical Medicine/Rheumatology, Umeå Universitet, Umeå, Sweden PubMed articles Google scholar articles
Kristina Forslind Department of Clinical Sciences, Section of Rheumatology, Faculty of Medicine, Lund University, Lund, Sweden Spenshult Research and Development Center, Halmstad, Sweden PubMed articles Google scholar articles
Erik Lönnblom Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles
Min Yang Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles
Bingze Xu Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles
Qixing Li Center for Medical Immunopharmacology Research, Southern Medical University, Guangzhou, China PubMed articles Google scholar articles
Lei Cheng Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles
Göran Bergström Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden PubMed articles Google scholar articles
Gonzalo Fernandez Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles
Alf Kastbom Department of Rheumatology and Department of Biochemical and Clinical Sciences, Linköping University, Linköping, Sweden PubMed articles Google scholar articles
Solbritt Rantapää-Dahlqvist Department of Public Health and Clinical Medicine/Rheumatology, Umeå Universitet, Umeå, Sweden PubMed articles Google scholar articles
Inger Gjertsson Department of Rheumatology and Inflammation Research, University of Gothenburg Sahlgrenska Academy, Göteborg, Sweden Rheumatology, Sahlgrenska University Hospital, Göteborg, Sweden PubMed articles Google scholar articles
Rikard Holmdahl Section of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden PubMed articles Google scholar articles

Correspondence to Professor Rikard Holmdahl, Medical Inflammation Research, Karolinska Institute, Stockholm 171 77, Sweden; rikard.holmdahl{at}ki.se

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Citation

Li T, Ge C, Krämer A, et al

Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage

Annals of the Rheumatic Diseases 2023;82:799-808.

Publication history

Received November 16, 2022
Accepted February 15, 2023
First published March 1, 2023.

Online issue publication

October 18, 2023

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