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  • Response to: ‘Correspondence on ‘Risk of venous thromboembolism in knee, hip and hand osteoarthritis: a general population-based cohort study’’ by Lin et al

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Correspondence response
Response to: ‘Correspondence on ‘Risk of venous thromboembolism in knee, hip and hand osteoarthritis: a general population-based cohort study’’ by Lin et al
  1. Chao Zeng1,2,3,4,
  2. Zidan Yang4,
  3. Guanghua Lei1,4,5,
  4. Yuqing Zhang2,3
  1. 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China
  2. 2 Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
  3. 3 The Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
  4. 4 Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China
  5. 5 National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
  1. Correspondence to Guanghua Lei, Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China; lei_guanghua{at}csu.edu.cn; Yuqing Zhang, Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; yzhang108{at}mgh.harvard.edu

http://dx.doi.org/10.1136/annrheumdis-2020-219747

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    Lin et al 1 raised three points with regard to residual confounding to affect our findings. Below we provide point-by-point replies to the three comments.

    First, we agree that immobilisation duration is a strong risk factor for postoperative venous thromboembolism (VTE). The aim of our study was to examine the relation of incident osteoarthritis (OA) to the risk of VTE (ie, the total effect) and to assess to what extent the effect of incident OA on the risk of VTE is through its effect on knee/hip replacement (ie, the indirect effect).2 Since …

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    Footnotes

    • Handling editor Josef S Smolen

    • Correction notice This article has been corrected since it published Online First. The provenance and peer review statement has been included.

    • Contributors All authors have read, provided critical feedback on intellectual content and approved the final manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Commissioned; internally peer reviewed.

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