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I read with great interest the article published by Abtahi et al recently.1 The authors aimed to investigate the association between concomitant use of oral glucocorticoids (GCs) and proton pump inhibitors (PPIs) and the risk of osteoporotic fractures among patients with rheumatoid arthritis.1 The study showed that concomitant current use of oral GCs and PPIs was associated with increased risk of osteoporotic fractures compared with non-use (adjusted HR: 1.60, 95% CI: 1.35 to 1.89). Both oral GC and PPI use alone were also associated with increased risk of osteoporotic fracture compared with non-use (adjusted HR: 1.23, 95% CI: 1.03 to 1.47 (oral GC use alone); adjusted HR: 1.22, 95% CI: 1.05 to 1.42 (PPI …
Contributors BKZ: Wrote and revised the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; internally peer reviewed.